Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367311 | 0.84 | TLR3 (0.44) | TLR3NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL10365146 | 0.74 | HTR2A (0.37) | TLR3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10482681 | 0.68 | TLR3 (0.39) | TLR3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10365140 | 0.68 | MAOB (0.54) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL10366315 | 0.67 | HTR2A (0.37) | ALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL10366317 | 0.67 | KDM4E (0.38) | ALDH1A1KMT2ACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7761819 | 0.65 | KMT2A (0.58) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL7328515 | 0.64 | TDP1 (0.50) | NPC1RAB9AALDH1A1HTR2A | |
| SCHEMBL6937137 | 0.64 | KCNE1 (0.55) | TLR3NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7338569 | 0.64 | TDP1 (0.50) | NPC1RAB9AALDH1A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089781-B1 | BICYCLIC BENZO FUSED COMPOUNDS | PFIZER INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4870084-A | ANALGESICS, ANTIDIARRHEALS | PFIZER INC. (US) | 1989-09-26 | — | — | US | disclosed |
| US-4863934-A | Bicyclic benzo fused pyran compounds used for producing analgesia | PFIZER INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4841078-A | ANALGESICS | PFIZER INC. (US) | 1989-06-20 | — | — | US | disclosed |
| US-4680404-A | ANALGESICS, TRANQUILIZERS, ANTIEMETICS, DIURETICS, ANTICONVULSANTS | PFIZER INC. (US) | 1987-07-14 | — | — | US | disclosed |
| US-4486428-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1984-12-04 | — | — | US | disclosed |
| EP-0089781-A2 | Bicyclic benzo fused compounds | PFIZER INC. (US) | 1983-09-28 | — | — | EP | disclosed |