Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366281 | 1.00 | MAPT (0.41) | MAPTSLC6A9ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10366232 | 0.77 | ERN1 (0.48) | ALDH1A1SMN1; SMN2LMNAGAAERN1 | |
| SCHEMBL7211706 | 0.76 | MEN1 (0.48) | MAPTALDH1A1KMT2ALMNAHTT | |
| SCHEMBL10366785 | 0.75 | SLC6A9 (0.40) | MAPTSLC6A9ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10958722 | 0.70 | PGR (0.44) | ALDH1A1SMN1; SMN2LMNAGAAERN1 | |
| SCHEMBL7365668 | 0.69 | MEN1 (0.42) | MAPTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL9479673 | 0.65 | MAPT (0.52) | MAPTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7791640 | 0.64 | MEN1 (0.41) | MAPTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6266662 | 0.64 | CA2 (0.61) | MAPTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3261357 | 0.62 | CA2 (0.50) | MAPTALDH1A1SMN1; SMN2ERN1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199235-B1 | PHENYLALKYL-2,3-DIHYDROBENZOFURANS AND ANALOGS USEFUL AS ANTI-INFLAMMATORY AGENTS | MERCK & CO. INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4775679-A | Certain heterocyclic-ethyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents | MERCK & CO., INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4713393-A | TOPICAL TREATMENT OF SKIN DISORDERS | MERCK & CO., INC. (US) | 1987-12-15 | — | — | US | disclosed |
| EP-0199235-A2 | Phenylalkyl-2,3-dihydrobenzofurans and analogs useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |