Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.58 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | F11 | P03951 | 1/20 | 0.47 |
| ▸ | CYCS | P99999 | 2/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356704 | 0.85 | CA12 (0.55) | GRIK1GRIK2GRIK3CA12CA9 | |
| SCHEMBL1050811 | 0.85 | CA12 (0.55) | GRIK1GRIK2GRIK3CA12CA9 | |
| SCHEMBL10368097 | 0.84 | CA12 (0.47) | GRIK1GRIK2GRIK3CA12CA9 | |
| SCHEMBL10366372 | 0.83 | CA12 (0.46) | GRIK1GRIK2GRIK3CA12CA9 | |
| SCHEMBL4552802 | 0.82 | CA12 (0.57) | CA12CA9F11HPGDPOLB | |
| SCHEMBL4290533 | 0.80 | CA12 (0.53) | CA12CA9F11CA1CA3 | |
| SCHEMBL3399995 | 0.77 | RIPK1 (0.46) | GRIK1GRIK2GRIK3CA12CA9 | |
| SCHEMBL2324527 | 0.77 | F11 (0.73) | CA12CA9F11CASP3SENP8 | |
| SCHEMBL16573987 | 0.77 | CA12 (0.73) | CA12CA9F11HPGDKDM4E | |
| SCHEMBL10367636 | 0.77 | RXRA (0.47) | GRIK1GRIK2GRIK3RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190857-B1 | QUINOLONE INOTROPIC AGENTS | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |
| US-4728654-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0190857-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-08-13 | — | — | EP | disclosed |