SCHEMBL10366394

SCHEMBL10366394

CC(C)(c1ccccc1)C1Cc2ccccc2O1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.38
CHRM2 P08172 2/20 0.38
CHRM4 P08173 2/20 0.38
CHRM5 P08912 2/20 0.38
CHRM1 P11229 2/20 0.38
CHRM3 P20309 2/20 0.38
SSTR4 P31391 1/20 0.38
MAOB P27338 6/20 0.35
AOC2 O75106 5/20 0.35
MAOA P21397 5/20 0.35
DAO P14920 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
KDM4E B2RXH2 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
AR P10275 1/20 0.33
CYP19A1 P11511 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11952613 0.82 SSTR4 (0.41) HIF1ACHRM2CHRM4CHRM5CHRM1
SCHEMBL10877666 0.79 HIF1A (0.52) HIF1ASSTR4HPGDKDM4E
SCHEMBL8035974 0.79 AOC2 (0.40) HIF1ACHRM2CHRM4CHRM5CHRM1
SCHEMBL7279348 0.78 SSTR4 (0.45) HIF1ASSTR4MAOBAOC2MAOA
SCHEMBL12911435 0.74 MAOA (0.41) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL2152425 0.72 SSTR4 (0.36) HIF1ACHRM2CHRM4CHRM5CHRM1
SCHEMBL8036060 0.72 SSTR4 (0.43) HIF1ACHRM2CHRM4CHRM5CHRM1
SCHEMBL6473349 0.69 CYP19A1 (0.37) HIF1ACHRM2CHRM4CHRM5CHRM1
SCHEMBL6477728 0.69 CYP19A1 (0.37) HIF1ACHRM2CHRM4CHRM5CHRM1
SCHEMBL23867147 0.68 HSP90AB1 (0.44) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0207605-B1 HYPOGLYCEMIC THIAZOLIDINEDIONES PFIZER INC. (US) 1990-02-07 EP disclosed
US-4703052-A Hypoglycemic thiazolidinediones PFIZER INC. (US) 1987-10-27 US disclosed
EP-0207605-A1 Hypoglycemic thiazolidinediones PFIZER INC. (US) 1987-01-07 EP disclosed
WO-1986007056-A1 HYPOGLYCEMIC THIAZOLIDINEDIONES PFIZER INC. (US) 1986-12-04 WO disclosed