Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.51 |
| ▸ | SLC8A1 | P32418 | 17/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16381954 | 0.79 | ALDH1A1 (0.42) | ESR1ESR2 | |
| SCHEMBL4361595 | 0.78 | ESR2 (0.82) | ESR1ESR2SLC8A1AR | |
| SCHEMBL11050129 | 0.78 | ESR1 (0.55) | ESR1ESR2SLC8A1 | |
| SCHEMBL25294651 | 0.78 | ESR1 (0.55) | ESR1ESR2SLC8A1 | |
| SCHEMBL11053787 | 0.78 | ESR1 (0.59) | ESR1ESR2SLC8A1AR | |
| SCHEMBL9151283 | 0.77 | HTR1A (0.45) | — | |
| SCHEMBL8804880 | 0.77 | HTR1A (0.45) | — | |
| Flavane SCHEMBL14394530 | 0.76 | ESR1 (0.51) | ESR1ESR2SLC8A1AR | |
| Flavane SCHEMBL123287 | 0.76 | ESR1 (0.51) | ESR1ESR2SLC8A1AR | |
| Flavane SCHEMBL29478071 | 0.76 | ESR1 (0.51) | ESR1ESR2SLC8A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207605-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4703052-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0207605-A1 | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |