Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367282 | 1.00 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL197128 | 0.81 | MME (0.42) | CHRNB2CHRNA4MME | |
| SCHEMBL197129 | 0.81 | MME (0.42) | CHRNB2CHRNA4MME | |
| SCHEMBL26205780 | 0.79 | TSHR (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL196403 | 0.79 | ALDH1A1 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL26205798 | 0.79 | TSHR (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL196404 | 0.79 | ALDH1A1 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL197546 | 0.76 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL197545 | 0.76 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL19230444 | 0.73 | ALDH1A1 (0.36) | RNPEPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148883-B1 | ALLOPURINOL PRODRUGS | A/S GEA Farmaceutisk Fabrik (DK) | 1990-02-14 | — | — | EP | disclosed |
| US-4694006-A | Acyl- or acyloxymethyl-allopurinol prodrugs | A/S GEA (DK) | 1987-09-15 | — | — | US | disclosed |
| EP-0148883-A1 | ALLOPURINOL PRODRUGS. | GEA AS (DK) | 1985-07-24 | — | — | EP | disclosed |
| WO-1985000368-A1 | ALLOPURINOL PRODRUGS | A/S GEA (DK) | 1985-01-31 | — | — | WO | disclosed |