Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10912364 | 0.83 | LMNA (0.64) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL18499136 | 0.76 | KCNH2 (0.48) | NPC1MAPTMEN1KMT2ALMNA | |
| SCHEMBL2118439 | 0.75 | ALDH1A1 (0.54) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL338452 | 0.74 | CLK4 (0.64) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL15805573 | 0.73 | ESR2 (0.72) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1645118 | 0.73 | CHRNA7 (0.55) | NPC1MAPTRAB9ASMN1; SMN2CLK4 | |
| SCHEMBL7801135 | 0.73 | CHRNA7 (0.55) | NPC1MAPTRAB9ASMN1; SMN2CLK4 | |
| SCHEMBL2876553 | 0.72 | CLK4 (0.61) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL15896952 | 0.72 | CLK4 (0.61) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7377873 | 0.72 | ESR1 (0.55) | NPC1MAPTRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810071-B | miRNA biosynthesis inhibitor | 中国科学院成都生物研究所 | 2023-04-21 | — | — | CN | disclosed |
| CN-109810071-A | A kind of miRNA biosynthesis inhibitor | 中国科学院成都生物研究所 | 2019-05-28 | — | — | CN | disclosed |
| EP-0153746-B1 | 3-AMINO-2-HYDROXYPROPYL DERIVATIVES OF PYRIMIDIN-4-ONE | MERCK & CO. INC. (US) | 1990-11-22 | — | — | EP | disclosed |