⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359025 | 0.71 | — | — | |
| SCHEMBL321826 | 0.65 | — | — | |
| SCHEMBL6355846 | 0.64 | ALOX15 (0.37) | — | |
| SCHEMBL7640633 | 0.62 | — | — | |
| SCHEMBL6348411 | 0.62 | ALDH1A1 (0.38) | — | |
| SCHEMBL4482683 | 0.62 | — | — | |
| SCHEMBL9579055 | 0.59 | — | — | |
| SCHEMBL15196104 | 0.59 | — | — | |
| SCHEMBL9976688 | 0.59 | — | — | |
| SCHEMBL183913 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199968-A1 | Thiazole derivatives | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-11-05 | — | — | EP | claimed |
| JP-61085386-A | — | — | None | — | — | JP | disclosed |
| US-8461163-B2 | Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-8461163-B2 | Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110077235-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-31 | — | — | US | disclosed |
| EP-0199968-B1 | THIAZOLE DERIVATIVES | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-02-28 | — | — | EP | disclosed |
| US-4804668-A | CARDIOTONIC AGENTS | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-02-14 | — | — | US | disclosed |
| US-4800201-A | 1,4-thiazine derivative, and cardiotonic agent comprising it as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-24 | — | — | US | disclosed |
| EP-0138058-B1 | NOVEL 1,4-THIAZINE DERIVATIVE | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1988-08-17 | — | — | EP | disclosed |
| EP-0233287-A1 | 1,4-THIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND CARDIOTONICS CONTAINING THE SAME | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 1987-08-26 | — | — | EP | disclosed |
| EP-0199968-A1 | Thiazole derivatives | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-11-05 | — | — | EP | disclosed |
| JP-S6185386-A | NOVEL 1, 4-THIAZINE DERIVATIVE AND ITS PREPARATION | ZENYAKU KOGYO KK | 1986-04-30 | — | — | JP | disclosed |
| US-4565813-A | CARDIOTONIC AGENTS, CONDENSATION OR PYRIDINE AND 1,4-THIAZINEONE | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-01-21 | — | — | US | disclosed |
| EP-0138058-A1 | Novel 1,4-thiazine derivative | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1985-04-24 | — | — | EP | disclosed |
| JP-S06185386-A | — | — | 0001-01-01 | — | — | JP | disclosed |