Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | CBX7 | O95931 | 1/20 | 0.34 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10374079 | 0.90 | POLB (0.39) | RAD52ALDH1A1MAPTPKMLMNA | |
| SCHEMBL10370674 | 0.81 | RAD52 (0.48) | RAD52ALDH1A1MAPTPKMLMNA | |
| SCHEMBL10693548 | 0.80 | RAD52 (0.35) | RAD52ALDH1A1MAPTPKMOPRM1 | |
| SCHEMBL10771121 | 0.80 | RAD52 (0.35) | RAD52ALDH1A1MAPTPKMLMNA | |
| SCHEMBL10696619 | 0.79 | RAD52 (0.34) | RAD52ALDH1A1MAPTPKMOPRM1 | |
| SCHEMBL10370705 | 0.78 | ALDH1A1 (0.36) | RAD52ALDH1A1MAPTPKMLMNA | |
| SCHEMBL10694665 | 0.77 | RAD52 (0.36) | RAD52ALDH1A1MAPTPKMLMNA | |
| SCHEMBL10690584 | 0.76 | ALDH1A1 (0.36) | RAD52ALDH1A1MAPTPKMOPRM1 | |
| Hydrochloric Acid SCHEMBL10409299 | 0.76 | LMNA (0.43) | ALDH1A1MAPTLMNAKDM4EOPRM1 | |
| Hydrochloric Acid SCHEMBL10369431 | 0.74 | SMPD1 (0.49) | MAPTLMNAKDM4ENPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212481-B1 | INDOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-12 | — | — | EP | disclosed |
| US-4952598-A | CALCIUM ANTAGONISTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-28 | — | — | US | disclosed |
| US-4882329-A | CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0212481-A1 | Indolinone derivatives, processes for their preparation, pharmaceutical compounds containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |