Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 7/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696619 | 0.99 | RAD52 (0.34) | RAD52POLBHSD17B10DRD2HTT | |
| SCHEMBL10694665 | 0.97 | RAD52 (0.36) | RAD52POLBHSD17B10DRD2HTT | |
| SCHEMBL10690584 | 0.84 | ALDH1A1 (0.36) | RAD52POLBHSD17B10DRD2HTT | |
| SCHEMBL10691597 | 0.82 | ADRA1A (0.39) | RAD52DRD2ALDH1A1MAPTADRA1D | |
| SCHEMBL10694109 | 0.82 | POLB (0.35) | POLBHSD17B10DRD2HTTALDH1A1 | |
| SCHEMBL10692186 | 0.81 | BACE1 (0.35) | HSD17B10DRD2HTTALDH1A1MAPT | |
| SCHEMBL10691306 | 0.80 | ALDH1A1 (0.41) | RAD52POLBHSD17B10HTTALDH1A1 | |
| SCHEMBL10368985 | 0.80 | RAD52 (0.41) | RAD52HSD17B10DRD2HTTALDH1A1 | |
| SCHEMBL10692789 | 0.80 | BACE1 (0.37) | POLBHSD17B10HTTALDH1A1SLC6A2 | |
| SCHEMBL10694576 | 0.80 | POLB (0.33) | POLBHSD17B10DRD2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |