Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL7944626 | 0.98 | CA2 (0.41) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL21268045 | 0.95 | CA2 (0.39) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL4388860 | 0.90 | CA2 (0.46) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL1450459 | 0.89 | CA2 (0.35) | CA2CA4CES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL7060294 | 0.89 | CES2 (0.45) | CES2CES1ALDH1A1TSHRSMN1; SMN2 | |
| Acetic Acid SCHEMBL7063597 | 0.88 | CES2 (0.44) | CA2CES2CES1ALDH1A1CA1 | |
| Tetraphenylphosphonium SCHEMBL1155888 | 0.87 | CA2 (0.44) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL7616105 | 0.86 | CA2 (0.57) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL27377661 | 0.85 | CES2 (0.41) | CES2CES1ALDH1A1CYP1A2CYP2D6 | |
| Tetraphenylphosphonium SCHEMBL8143595 | 0.84 | TSHR (0.43) | CES2CES1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 612 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11945909-B2 | Process for preparing polycarbonates using a catalyst system having a quarternary nitrogen compond and a quarternary phosphorous compound | EPC Engineering & Technologies GmbH (DE) | 2024-04-02 | — | — | US | claimed |
| EP-3526274-B1 | CATALYST SYSTEM | EPC ENGINEERING & TECH GMBH (DE) | 2022-08-03 | — | — | EP | claimed |
| EP-3129423-B1 | A SYSTEM AND PROCESS FOR PRODUCING VARIOUS MOLECULAR WEIGHT MELT POLYCARBONATES | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2022-05-25 | — | — | EP | claimed |
| EP-3221380-B1 | A METHOD OF POLYMERIZING END-CAPPED POLYCARBONATE AND END-CAPPED POLYCARBONATES DERIVED THEREFROM | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2021-10-20 | — | — | EP | claimed |
| EP-2981560-B1 | CURING OF LIQUID THERMOSETTING RESINS | REICHHOLD LLC 2 (US) | 2021-10-13 | — | — | EP | claimed |
| EP-3262098-B1 | CONTROL OF ORGANIC IMPURITIES IN POLYCARBONATE SYNTHESIS | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2021-06-16 | — | — | EP | claimed |
| EP-2947110-B1 | MELT FILTER ALIGNMENT IN A CONTINUOUS MELT POLYCARBONATE PRODUCTION PROCESS | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2021-03-24 | — | — | EP | claimed |
| US-10544299-B2 | Vinyl-containing compounds with high heat distortion | REICHHOLD LLC 2 (US) | 2020-01-28 | — | — | US | claimed |
| CN-107075098-B | Method of polymerizing end-capped polycarbonates and end-capped polycarbonates derived therefrom | 沙特基础工业全球技术有限公司 | 2019-12-24 | — | — | CN | claimed |
| US-20190345335-A1 | Preparation method of polyorganosiloxane-polycarbonate and its application | Guangdong Great Material Co., Ltd. (CN) | 2019-11-14 | — | — | US | claimed |
| US-20060093974-A1 | Thermally developable materials processable at lower temperatures | EASTMAN KODAK COMPANY | 2006-05-04 | — | — | US | claimed |
| EP-1578840-A1 | METHOD FOR THE PRODUCTION OF POLYCARBONATES | General Electric Company (US) | 2005-09-28 | — | — | EP | claimed |
| EP-1560871-A1 | METHOD FOR MAKING COPOLYCARBONATES | GENERAL ELECTRIC COMPANY (US) | 2005-08-10 | — | — | EP | claimed |
| WO-2004060963-A1 | METHOD FOR THE PRODUCTION OF POLYCARBONATES | GENERAL ELECTRIC COMPANY (US) | 2004-07-22 | — | — | WO | claimed |
| WO-2004041907-A1 | METHOD FOR MAKING COPOLYCARBONATES | GENERAL ELECTRIC COMPANY (US) | 2004-05-21 | — | — | WO | claimed |
| US-6657038-B1 | Melt condensation copolymerization of dihydroxyaromatic compounds and diphenyl carbonate derivative in presence of metal hydroxide and quaternary phosphonium salt | GENERAL ELECTRIC COMPANY | 2003-12-02 | — | — | US | claimed |
| EP-0671428-B1 | Method for making polycarbonates | GEN ELECTRIC (US) | 2002-08-21 | — | — | EP | claimed |
| US-6316575-B1 | MELT TRANSESTERIFICATION OF DIOL COMPOUND AND CARBOANTE COMPOUND USING CATALYST COMPRISING A PHOSPHORUS-CONTAINING BASIC COMPOUND QUATERNARY PHOSPHONIUM SALT TO FORM POLYCARBONATE | IDEMITSU KOSAN CO., LTD. (JP) | 2001-11-13 | — | — | US | claimed |
| EP-0671428-A1 | Method for making polycarbonates | GENERAL ELECTRIC COMPANY (US) | 1995-09-13 | — | — | EP | claimed |
| US-5412061-A | Polycarbonate melt condensation synthesis using a tetraorganophosphonium carboxylate salt catalyst | GENERAL ELECTRIC COMPANY (US) | 1995-05-02 | — | — | US | claimed |