Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL7944626 | 0.98 | CA2 (0.41) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL1037056 | 0.95 | CA2 (0.42) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL4388860 | 0.85 | CA2 (0.46) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL1450459 | 0.85 | CA2 (0.35) | CA2CA4CES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL7060294 | 0.85 | CES2 (0.45) | CES2CES1ALDH1A1TSHRSMN1; SMN2 | |
| Acetic Acid SCHEMBL7063597 | 0.84 | CES2 (0.44) | CA2CES2CES1ALDH1A1CYP1A2 | |
| Tetraphenylphosphonium SCHEMBL1155888 | 0.83 | CA2 (0.44) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL7616105 | 0.82 | CA2 (0.57) | CA2CA4CES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL9603209 | 0.82 | CA2 (0.39) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL27377661 | 0.81 | CES2 (0.41) | CES2CES1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526274-A1 | CATALYST SYSTEM | EPC Engineering & Technologies GmbH (DE) | 2019-08-21 | — | — | EP | claimed |