Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL21268045 | 0.98 | CA2 (0.39) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL1037056 | 0.98 | CA2 (0.42) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL4388860 | 0.87 | CA2 (0.46) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL1450459 | 0.87 | CA2 (0.35) | CA2CA4CES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL7060294 | 0.87 | CES2 (0.45) | CES2CES1ALDH1A1TSHRSMN1; SMN2 | |
| Acetic Acid SCHEMBL7063597 | 0.86 | CES2 (0.44) | CA2CES2CES1ALDH1A1CYP1A2 | |
| Tetraphenylphosphonium SCHEMBL1155888 | 0.85 | CA2 (0.44) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL7616105 | 0.84 | CA2 (0.57) | CA2CA4CES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL9603209 | 0.84 | CA2 (0.39) | CA2CA4CES2CES1ALDH1A1 | |
| Tetraphenylphosphonium SCHEMBL27377661 | 0.83 | CES2 (0.41) | CES2CES1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110770274-B | Powder coating compositions containing aromatic polymerizates of aromatic isocyanate production processes | 科思创有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-110770273-B | Powder coating compositions containing aromatic isocyanate-derived polymeric aromatic products | 科思创有限公司 | 2022-02-22 | — | — | CN | disclosed |
| EP-3642255-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | Covestro LLC (US) | 2020-04-29 | — | — | EP | disclosed |
| EP-3642254-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | Covestro LLC (US) | 2020-04-29 | — | — | EP | disclosed |
| CN-110770274-A | Powder coating compositions containing aromatic polymerizates of aromatic isocyanate production processes | 科思创有限公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-110770273-A | Powder coating compositions containing aromatic isocyanate-derived polymeric aromatic products | 科思创有限公司 | 2020-02-07 | — | — | CN | disclosed |
| US-10465090-B2 | Powder coating compositions with a polymeric aromatic product of an aromatic isocyanate manufacturing process | COVESTRO LLC (US) | 2019-11-05 | — | — | US | disclosed |
| US-10400112-B2 | Powder coating compositions with a polymeric aromatic product of an aromatic isocyanate manufacturing process | COVESTRO LLC (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180371263-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC | 2018-12-27 | — | — | US | disclosed |
| US-20180371287-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC | 2018-12-27 | — | — | US | disclosed |
| WO-2018236972-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC (US) | 2018-12-27 | — | — | WO | disclosed |
| WO-2018236975-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | COVESTRO LLC (US) | 2018-12-27 | — | — | WO | disclosed |
| WO-2001094463-A1 | POWDER COATING OF EPOXY RESIN, CARBOXYLIC ACID-TERMINATED POLYESTER, STYRENE-MALEIC | SARTOMER TECHNOLOGY COMPANY, INC. (US) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180371287-A1 | POWDER COATING COMPOSITIONS WITH A POLYMERIC AROMATIC PRODUCT OF AN AROMATIC ISOCYANATE MANUFACTURING PROCESS | PAH, ALKBH3, AHR | CA2 3141/4885CA4 898/4885CES2 3285/4885 |
| US-10465090-B2 | Powder coating compositions with a polymeric aromatic product of an aromatic isocyanate manufacturing process | PAH, ALKBH3, AHR | CA2 3141/4885CA4 898/4885CES2 3285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.