Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.56 |
| ▸ | PDE2A | O00408 | 3/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 5/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280962 | 0.72 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10353452 | 0.71 | SMN1; SMN2 (0.81) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL7288026 | 0.71 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11035016 | 0.70 | SMN1; SMN2 (0.68) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL6495298 | 0.69 | SMN1; SMN2 (0.60) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10371773 | 0.68 | TSHR (0.32) | TSHR | |
| SCHEMBL9631025 | 0.68 | SMN1; SMN2 (0.55) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL6559298 | 0.68 | KCNH2 (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10745350 | 0.68 | MAPT (0.60) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8481664 | 0.68 | LMNA (0.56) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231744-B1 | SUBSTITUTED PYRROL-1-YLPHENYLDIHYDROPYRIDAZINONES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0231744-A1 | Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use | BASF Aktiengesellschaft (DE) | 1987-08-12 | — | — | EP | disclosed |