Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30945720 | 0.93 | SIGMAR1 (0.66) | ACHESIGMAR1 | |
| SCHEMBL10668365 | 0.91 | GRIN2B (0.70) | SIGMAR1 | |
| SCHEMBL10662730 | 0.90 | HTR1A (0.69) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10667418 | 0.90 | GRIN2B (0.69) | BCHEACHESIGMAR1 | |
| SCHEMBL10666818 | 0.87 | GRIN2B (0.75) | SIGMAR1 | |
| SCHEMBL10375595 | 0.86 | SIGMAR1 (0.94) | SIGMAR1 | |
| SCHEMBL10375901 | 0.86 | SIGMAR1 (0.73) | ACHESIGMAR1 | |
| SCHEMBL10375956 | 0.84 | SIGMAR1 (0.63) | BCHEACHESIGMAR1 | |
| SCHEMBL10668586 | 0.83 | GRIN2B (0.66) | SIGMAR1 | |
| SCHEMBL10375702 | 0.82 | SIGMAR1 (1.00) | ACHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | claimed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | claimed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | claimed |
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | disclosed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |