Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376475 | 0.79 | MAPT (0.45) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| Mitoquidone SCHEMBL93910 | 0.78 | MAOA (0.43) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| Mitoquidone SCHEMBL21570575 | 0.77 | MAPT (0.38) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10376125 | 0.76 | MAPT (0.46) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL10376482 | 0.75 | EGFR (0.45) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL10376448 | 0.74 | MAOA (0.50) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL10376512 | 0.73 | ALDH1A1 (0.51) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL10391087 | 0.72 | TTR (0.43) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL29551111 | 0.72 | MAPT (0.60) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL497339 | 0.72 | MAPT (0.60) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161102-B1 | ISOQUINOLINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-02-21 | — | — | EP | claimed |
| EP-0161102-A2 | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1985-11-13 | — | — | EP | claimed |
| EP-0161102-B1 | ISOQUINOLINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-02-21 | — | — | EP | disclosed |
| US-4835158-A | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1989-05-30 | — | — | US | disclosed |
| EP-0161102-A2 | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1985-11-13 | — | — | EP | disclosed |