Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803476 | 0.92 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9799559 | 0.88 | CYP1A2 (0.44) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9799463 | 0.86 | KAT2B (0.45) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL10377267 | 0.85 | KAT2B (0.42) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL10377172 | 0.85 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9351767 | 0.83 | FEN1 (0.54) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL9767592 | 0.81 | ALDH1A1 (0.57) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL10724630 | 0.80 | ALDH1A1 (0.56) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL10812533 | 0.80 | ALDH1A1 (0.56) | PDE4APDE4BPDE4CPDE4DFEN1 | |
| SCHEMBL10421494 | 0.80 | FEN1 (0.51) | PDE4APDE4BPDE4CPDE4DFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |