Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 14/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378395 | 1.00 | FBP1 (0.52) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6910818 | 0.73 | FBP1 (0.78) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6910815 | 0.73 | FBP1 (0.78) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL24664061 | 0.71 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL510539 | 0.69 | HSP90AA1 (0.55) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL510540 | 0.69 | HSP90AA1 (0.55) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17848061 | 0.69 | MAOA (0.47) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17848062 | 0.69 | MAOA (0.47) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8800866 | 0.68 | FBP1 (0.51) | FBP1ALDH1A1LMNASMN1; SMN2EGFR | |
| SCHEMBL366122 | 0.68 | FBP1 (1.00) | FBP1ALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172692-B1 | HEXAHYDROINDOLIZINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS AND INTERMEDIATES | McNeilab, Inc. (US) | 1990-04-18 | — | — | EP | disclosed |
| EP-0172692-A1 | Hexahydroindolizine compounds, pharmaceutical compositions and methods and intermediates | McNeilab, Inc. (US) | 1986-02-26 | — | — | EP | disclosed |
| US-4572911-A | ANTISECRETORY AND ANTIDEPRESSANT AGENTS | MCNEILAB, INC. (US) | 1986-02-25 | — | — | US | disclosed |
| US-4002643-A | REARRANGING WITH A STRONG, ANHYDROUS, NON-OXIDIZING ACID | MCNEIL LABORATORIES, INC. (US) | 1977-01-11 | — | — | US | disclosed |