Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176426 | 0.81 | KDM4E (0.43) | GAAMEN1KMT2ATSHRMAPT | |
| SCHEMBL1038020 | 0.80 | IDO1 (0.46) | GAAMEN1HPGDKMT2AIDO1 | |
| SCHEMBL30747808 | 0.78 | TSHR (0.58) | GAAMEN1HPGDKMT2ATSHR | |
| SCHEMBL9366709 | 0.74 | MAPT (0.49) | MEN1HPGDKMT2ATSHRMAPT | |
| SCHEMBL21138127 | 0.74 | CCNC (0.45) | IDO1AAK1SLC22A12 | |
| SCHEMBL24469567 | 0.73 | GAK (0.44) | IDO1AAK1SLC22A12 | |
| SCHEMBL28682421 | 0.73 | IDO1 (0.58) | IDO1 | |
| SCHEMBL28682418 | 0.73 | IDO1 (0.58) | IDO1 | |
| SCHEMBL5004400 | 0.73 | CASP1 (0.41) | MEN1KMT2ATSHRMAPTNPSR1 | |
| SCHEMBL21475931 | 0.73 | IDO1 (0.65) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012961-B2 | Tricyclic antibiotics | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-09-06 | — | — | US | disclosed |
| US-20110039836-A1 | TRICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-02-17 | — | — | US | disclosed |
| EP-2276766-A1 | TRICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009128019-A1 | TRICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039836-A1 | TRICYCLIC ANTIBIOTICS | OPRM1, UBE2D3, METTL3 | GAA 2909/4885MEN1 1111/4885HPGD 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.