Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 14/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10380728 | 0.90 | FFAR4 (0.43) | FFAR4GRIN2BDGAT1CYP11B1CYP11B2 | |
| SCHEMBL10326401 | 0.80 | MELK (0.39) | FFAR4GRIN2B | |
| SCHEMBL10379959 | 0.77 | DGAT1 (0.47) | DGAT1ADORA2AKCNH2 | |
| SCHEMBL14969248 | 0.77 | CYP11B1 (0.38) | FFAR4GRIN2BDGAT1CYP11B1CYP11B2 | |
| SCHEMBL14969247 | 0.77 | CYP11B1 (0.38) | FFAR4GRIN2BDGAT1CYP11B1CYP11B2 | |
| SCHEMBL16449188 | 0.76 | DGAT1 (0.46) | FFAR4DGAT1 | |
| SCHEMBL10325156 | 0.75 | DGAT1 (0.38) | GRIN2BDGAT1CYP11B1CYP11B2ADORA2A | |
| SCHEMBL12516589 | 0.75 | DGAT1 (0.45) | FFAR4DGAT1 | |
| SCHEMBL14665458 | 0.74 | DGAT1 (0.43) | DGAT1 | |
| SCHEMBL12516585 | 0.73 | DGAT1 (0.44) | FFAR4DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |