Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 11/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL10379802 | 0.97 | SLC7A5 (0.38) | SLC7A5RENITGA4ITGB1CTSC | |
| Tyrosine SCHEMBL294953 | 0.91 | REN (0.38) | SLC7A5RENITGA4 | |
| Tyrosine SCHEMBL9617523 | 0.90 | REN (0.39) | SLC7A5RENITGA4CTSC | |
| Dl-Phenylalanine SCHEMBL29176066 | 0.89 | REN (0.44) | SLC7A5RENCTSC | |
| Tyrosine SCHEMBL5151728 | 0.89 | REN (0.36) | SLC7A5RENITGA4 | |
| Tyrosine SCHEMBL21461820 | 0.89 | SLC7A5 (0.38) | SLC7A5RENITGA4ITGB1CTSC | |
| Tyrosine SCHEMBL29176062 | 0.87 | REN (0.39) | SLC7A5RENITGA4CTSC | |
| Tyrosine SCHEMBL20855327 | 0.87 | REN (0.35) | SLC7A5RENITGA4 | |
| Tyrosine SCHEMBL4612310 | 0.86 | SLC7A5 (0.48) | SLC7A5ITGA4ITGB1 | |
| Tyrosine SCHEMBL28626712 | 0.86 | SLC7A5 (0.48) | SLC7A5ITGA4ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990006369-A1 | USE OF HIV PROTEASE CLEAVAGE SITE TO EXPRESS MATURE PROTEINS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-14 | — | — | WO | claimed |