Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10381890 | 0.80 | GPR119 (0.53) | GPR119PDE3APDE4BPDE3BPDE4D | |
| SCHEMBL10374774 | 0.76 | PBRM1 (0.49) | GPR119PDE3APDE4BPDE3BPDE4D | |
| SCHEMBL10383108 | 0.73 | PDE3B (0.64) | PDE3APDE4BPDE3BPDE4DPDE4A | |
| SCHEMBL2539105 | 0.68 | ALDH1A1 (0.58) | LMNATDP1 | |
| SCHEMBL10368590 | 0.67 | PDE3A (0.60) | GPR119PDE3APDE4BPDE3BPDE4D | |
| SCHEMBL10381784 | 0.67 | GPR119 (0.46) | GPR119PDE3APDE3BLMNATDP1 | |
| SCHEMBL10381883 | 0.67 | PDE3B (0.57) | GPR119PDE3APDE4BPDE3BPDE4D | |
| SCHEMBL10553008 | 0.66 | PDE3B (0.57) | PDE3APDE4BPDE3BPDE4DPDE4A | |
| SCHEMBL9210783 | 0.66 | LMNA (0.48) | LMNATDP1METAP2 | |
| SCHEMBL10518557 | 0.66 | PDE3B (0.51) | GPR119PDE3APDE4BPDE3BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990001479-A1 | 4,5-DIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR PRODUCING THEM AND THEIR USE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1990-02-22 | — | — | WO | disclosed |