Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5655696 | 0.99 | TSHR (0.38) | TSHRHTTHPGDKDM4EALDH1A1 | |
| SCHEMBL1041732 | 0.79 | RAB9A (0.44) | TSHRHPGDALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1038962 | 0.78 | TSHR (0.40) | TSHRHTTHPGDKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5655535 | 0.78 | RAB9A (0.44) | TSHRHPGDALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1039363 | 0.78 | TSHR (0.46) | TSHRHTTHPGDKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5655852 | 0.77 | ALDH1A1 (0.40) | TSHRHTTHPGDKDM4EALDH1A1 | |
| SCHEMBL1042117 | 0.75 | HTT (0.40) | TSHRHTTHPGDSMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL5655231 | 0.74 | HTT (0.39) | TSHRHTTSMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5654423 | 0.74 | HDAC3 (0.38) | TSHRHTTHPGDKDM4EALDH1A1 | |
| SCHEMBL6273728 | 0.68 | HTT (0.47) | TSHRHTTHPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581490-B1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROLE-2-CARBOXAMIDES | GRUENENTHAL GMBH (DE) | 2011-01-26 | — | — | EP | claimed |
| US-7229991-B2 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | GRUENENTHAL GMBH (DE) | 2007-06-12 | — | — | US | claimed |
| US-20050288342-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | GRUENENTHAL GMBH (DE) | 2005-12-29 | — | — | US | claimed |
| US-7229991-B2 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | GRUENENTHAL GMBH (DE) | 2007-06-12 | — | — | US | disclosed |
| US-20050288342-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | GRUENENTHAL GMBH (DE) | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288342-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | QPCT, PGA5, ALDH18A1 | TSHR 3081/4885HTT 1897/4885HPGD 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.