Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 13/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10383380 | 0.95 | ACE (0.46) | SMN1; SMN2ACELMNAABCB11ACE2 | |
| SCHEMBL10385066 | 0.86 | ACE (0.49) | SMN1; SMN2ACELMNAABCB11ACE2 | |
| SCHEMBL10383403 | 0.86 | ACE (0.58) | SMN1; SMN2ACELMNAACE2 | |
| SCHEMBL10521977 | 0.85 | ACE (0.44) | SMN1; SMN2ACELMNAABCB11ACE2 | |
| SCHEMBL10521974 | 0.85 | ACE (0.44) | SMN1; SMN2ACELMNAABCB11ACE2 | |
| SCHEMBL10520260 | 0.84 | ACE (0.45) | SMN1; SMN2ACELMNAABCB11ACE2 | |
| SCHEMBL10520254 | 0.84 | ACE (0.45) | SMN1; SMN2ACELMNAABCB11ACE2 | |
| Maleic Acid SCHEMBL10383733 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2ACELMNAACE2POLB | |
| SCHEMBL10520986 | 0.80 | ACE (0.50) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| SCHEMBL10520981 | 0.80 | ACE (0.50) | SMN1; SMN2ACELMNAABCB11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977179-A | Inhibiting angiotensin converting enzyme | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1990-12-11 | — | — | US | disclosed |