Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 2/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10383871 | 1.00 | HTT (0.52) | HTTDNM1HSP90AA1RAD52PLA2G1B | |
| SCHEMBL9408649 | 0.96 | HTT (0.50) | HTTDNM1HSP90AA1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL6717011 | 0.95 | HTT (0.54) | HTTDNM1HSP90AA1RAD52PLA2G1B | |
| Bromide SCHEMBL28464145 | 0.91 | DNM1 (0.55) | HTTDNM1HSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL28458666 | 0.91 | DNM1 (0.55) | HTTDNM1HSP90AA1RAD52KMT2A | |
| Bromide SCHEMBL28458359 | 0.91 | DNM1 (0.55) | HTTDNM1HSP90AA1RAD52KMT2A | |
| SCHEMBL29270413 | 0.83 | TSHR (0.44) | HTTDNM1KMT2ABBOX1 | |
| Bromide SCHEMBL30402214 | 0.83 | DNM1 (0.52) | HTTDNM1HSP90AA1RAD52BBOX1 | |
| Hydrochloric Acid SCHEMBL7119651 | 0.81 | DNM1 (0.48) | DNM1 | |
| Acrylamide SCHEMBL6941037 | 0.80 | HTT (0.52) | HTTDNM1HSP90AA1RAD52PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959432-A | HEAT RESISTANCE | UNION CARBIDE CHEMICALS AND PLASTICS COMPANY INC. (US) | 1990-09-25 | — | — | US | disclosed |
| US-4889887-A | CROSSLINKED N-(ALKOXYMETHYLENE)ACRYLYL COMPOUNDS | UNION CARBIDE CHEMICALS AND PLASTICS COMPANY INC. (US) | 1989-12-26 | — | — | US | disclosed |