Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462759 | 0.86 | SLC22A1 (0.50) | DNM1SLC22A1TSHRALDH1A1TP53 | |
| Bromide SCHEMBL1461564 | 0.84 | ALDH1A1 (0.52) | DNM1SLC22A1TSHRALDH1A1TP53 | |
| Iodide SCHEMBL1461547 | 0.84 | SLC22A1 (0.48) | DNM1SLC22A1TSHRALDH1A1TP53 | |
| SCHEMBL9408557 | 0.82 | ALDH1A1 (0.48) | DNM1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL10383871 | 0.81 | HTT (0.52) | DNM1 | |
| Hydrochloric Acid SCHEMBL10384120 | 0.81 | HTT (0.52) | DNM1 | |
| Hydrochloric Acid SCHEMBL6717011 | 0.79 | HTT (0.54) | DNM1FAAH | |
| SCHEMBL1462733 | 0.79 | FAAH (0.42) | SLC22A1TSHRALDH1A1TP53CYP3A4 | |
| Acrylic Acid SCHEMBL5912915 | 0.77 | DNM1 (0.59) | DNM1SLC22A1TSHRALDH1A1TP53 | |
| SCHEMBL9408649 | 0.77 | HTT (0.50) | DNM1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822248-B1 | Cleaning material for contact lens | MENICON CO LTD (JP) | 2003-11-12 | — | — | EP | disclosed |
| US-5919742-A | SOLID FORM; BLEND OF NONIONIC ADDITION POLYMER SURFACTANTS AND CROSSLINKING AGENT | MENICON CO., LTD. (JP) | 1999-07-06 | — | — | US | disclosed |
| EP-0822248-A2 | Cleaning material for contact lens | Menicon Co., Ltd. (JP) | 1998-02-04 | — | — | EP | disclosed |