Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150687 | 0.86 | NPC1 (0.51) | SMN1; SMN2GAA | |
| SCHEMBL1760607 | 0.81 | NOTUM (0.62) | ALDH1A1SMN1; SMN2LMNANOTUMTP53 | |
| SCHEMBL1760604 | 0.81 | NOTUM (0.62) | ALDH1A1SMN1; SMN2LMNANOTUMTP53 | |
| SCHEMBL15187564 | 0.80 | NOTUM (0.65) | ALDH1A1KDM4ESMN1; SMN2LMNANOTUM | |
| SCHEMBL27852119 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2LMNANOTUM | |
| SCHEMBL7831498 | 0.72 | POLB (0.56) | ALDH1A1KDM4ESMN1; SMN2LMNANOTUM | |
| SCHEMBL2824161 | 0.71 | NOTUM (0.56) | ALDH1A1KDM4ENOTUMTP53 | |
| SCHEMBL10742367 | 0.71 | DRD2 (0.49) | ALDH1A1KDM4ELMNANOTUMTP53 | |
| SCHEMBL10743464 | 0.71 | DRD2 (0.49) | ALDH1A1KDM4ELMNANOTUMTP53 | |
| SCHEMBL11756352 | 0.71 | MTNR1A (0.48) | ALDH1A1KDM4ESMN1; SMN2LMNANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4912125-A | 2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles for reducing intraocular pressure | CIBA-GEIGY CORPORATION (US) | 1990-03-27 | — | — | US | disclosed |
| US-4908376-A | 2,3-dihydro-2-(4,5-dihydroimidazol-2-yl)-indoles in composition form for reducing intraocular pressure | CIBA-GEIGY CORPORATION (US) | 1990-03-13 | — | — | US | disclosed |