Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828478 | 0.85 | THRB (0.48) | THRBCNR1KLKB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9826567 | 0.84 | THRB (0.54) | ALOX15THRBCNR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9826852 | 0.82 | CNR1 (0.56) | ALOX15THRBCNR1ALDH1A1POLB | |
| SCHEMBL10483343 | 0.76 | THRB (0.63) | THRBCNR1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10412088 | 0.76 | MAPT (0.56) | THRBCNR1ALDH1A1POLBKMT2A | |
| SCHEMBL9826705 | 0.75 | ALOX15 (0.69) | ALOX15KLKB1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10385002 | 0.75 | THRB (0.51) | THRBCNR1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10411951 | 0.74 | ATM (0.53) | THRBALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL10386151 | 0.73 | ALOX15 (0.71) | ALOX15CNR1KLKB1ALDH1A1KMT2A | |
| SCHEMBL10411289 | 0.72 | THRB (0.61) | THRBCNR1ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | claimed |