Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889829 | 0.73 | PDK2 (0.36) | TSHRMAPTKEAP1KMT2A | |
| SCHEMBL23489760 | 0.73 | PDK2 (0.36) | TSHRMAPTKEAP1KMT2A | |
| SCHEMBL18892819 | 0.72 | PDK2 (0.36) | TSHRMAPTNPC1RAB9AKMT2A | |
| SCHEMBL6154951 | 0.72 | TOP2A (0.54) | TOP2ATOP2BEGFRCNR2TSHR | |
| SCHEMBL11734140 | 0.70 | TOP2A (0.48) | TOP2ATOP2BEGFRCNR2TSHR | |
| SCHEMBL1384962 | 0.70 | TSHR (0.57) | TOP2ATOP2BEGFRCNR2TSHR | |
| SCHEMBL6375190 | 0.70 | TSHR (0.48) | TOP2ATOP2BEGFRCNR2TSHR | |
| SCHEMBL9968895 | 0.69 | GABRA1 (0.41) | TSHRKMT2AIDO1 | |
| SCHEMBL1200951 | 0.68 | TSHR (0.41) | TSHRMAPTHSD17B10KMT2A | |
| SCHEMBL4239389 | 0.68 | FABP4 (0.48) | TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914127-A | HYDROXYMETHYLGLUTARIC ACID-COENZYME A REDUCTASE INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-03 | — | — | US | disclosed |
| EP-0217092-A2 | 3-Dimethyl-mevalonic-acid derivatives, process for their preparation, pharmaceutical compositions based on these compounds, their use and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-08 | — | — | EP | disclosed |