Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.65 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.65 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.65 |
| ▸ | CHRNG | P07510 | 4/20 | 0.65 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.65 |
| ▸ | CHRND | Q07001 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9596517 | 0.99 | SLC6A2 (0.64) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL10409618 | 0.87 | RAB9A (0.56) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL10411257 | 0.87 | SLC6A2 (0.49) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL9796840 | 0.85 | SLC6A2 (0.65) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL10391072 | 0.85 | SLC6A2 (0.65) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL10391005 | 0.83 | SLC6A2 (0.64) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL9796932 | 0.83 | SLC6A2 (0.64) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL9595857 | 0.78 | SLC6A3 (0.72) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL634327 | 0.78 | SLC6A2 (1.00) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL27744090 | 0.77 | ALDH1A1 (0.54) | ALDH1A1ATMMAPTTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963570-A | ANTIDEPRESSANTS; CENTRAL NERVOUS SYSTEM | LABORATOIRE L. LAFON (FR) | 1990-10-16 | — | — | US | claimed |
| EP-0138714-B1 | 1-(ACETYLAMINOPHENYL)-2-AMINO-PROPANONE DERIVATIVES, THEIR THERAPEUTICAL USE AND PROCESS FOR THEIR PREPARATION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-05-20 | — | — | EP | claimed |
| EP-0138714-A2 | 1-(Acetylaminophenyl)-2-amino-propanone derivatives, their therapeutical use and process for their preparation | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1985-04-24 | — | — | EP | claimed |
| EP-0174242-B1 | 1-(AMINO-PHENYL)-2-AMINO PROPANON DERIVATIVES, THEIR USE IN THERAPY AND PROCESS FOR THEIR PREPARATION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-01-13 | — | — | EP | disclosed |
| EP-0174242-A2 | 1-(Amino-phenyl)-2-amino propanon derivatives, their use in therapy and process for their preparation | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-03-12 | — | — | EP | disclosed |