Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.72 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.72 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.72 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.72 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.72 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.72 |
| ▸ | CHRNG | P07510 | 4/20 | 0.72 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.72 |
| ▸ | CHRND | Q07001 | 4/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9596951 | 0.99 | SLC6A3 (0.70) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL634327 | 0.82 | SLC6A2 (1.00) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL9796926 | 0.81 | SLC6A3 (0.60) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL9360364 | 0.81 | SLC6A3 (0.60) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1072701 | 0.81 | SLC6A2 (0.69) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL9796810 | 0.80 | SLC6A3 (0.58) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL9797234 | 0.80 | SLC6A3 (0.58) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL10728832 | 0.80 | SLC6A2 (0.68) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL9597385 | 0.80 | SLC6A3 (0.61) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 | |
| Bromide SCHEMBL13729160 | 0.80 | SLC6A2 (0.68) | SLC6A3SLC6A2CHRNB4CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236922-A | Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives | LABORATOIRE L. LAFON (FR) | 1993-08-17 | — | — | US | claimed |
| EP-0174242-B1 | 1-(AMINO-PHENYL)-2-AMINO PROPANON DERIVATIVES, THEIR USE IN THERAPY AND PROCESS FOR THEIR PREPARATION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-01-13 | — | — | EP | claimed |
| EP-0174242-A2 | 1-(Amino-phenyl)-2-amino propanon derivatives, their use in therapy and process for their preparation | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-03-12 | — | — | EP | claimed |
| EP-0174242-B1 | 1-(AMINO-PHENYL)-2-AMINO PROPANON DERIVATIVES, THEIR USE IN THERAPY AND PROCESS FOR THEIR PREPARATION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-01-13 | — | — | EP | disclosed |