Sugi Predict

Sugi Predict / Compounds / Sarcosine

Sarcosine

Sarcosine

SCHEMBL2368384

CNCC(=O)O.C[C@H](N)C(=O)O

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ PTGS2 P35354 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ GABRP O00591 2/20 0.39
▸ GABRD O14764 2/20 0.39
▸ GABRA1 P14867 2/20 0.39
▸ GABRB1 P18505 2/20 0.39
▸ GABRG2 P18507 2/20 0.39
▸ GABRB3 P28472 2/20 0.39
▸ GABRA5 P31644 2/20 0.39
▸ GABRA3 P34903 2/20 0.39
▸ GABRA2 P47869 2/20 0.39
▸ GABRB2 P47870 2/20 0.39
▸ GABRA4 P48169 2/20 0.39
▸ GABRE P78334 2/20 0.39
▸ GABRA6 Q16445 2/20 0.39
▸ GABRG1 Q8N1C3 2/20 0.39
▸ GABRG3 Q99928 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alanine SCHEMBL11511190 1.00 ALDH1A1 (0.40) ALDH1A1LMNAMAPTPTGS2TDP1
Alanine SCHEMBL28294968 1.00 ALDH1A1 (0.40) ALDH1A1LMNAMAPTPTGS2TDP1
Sarcosine SCHEMBL17258535 0.96 ALDH1A1 (0.38) ALDH1A1LMNAMAPTPTGS2TDP1
Sarcosine SCHEMBL10395802 0.94 GLRA1 (0.42) ALDH1A1LMNAMAPTPTGS2TDP1
Sarcosine SCHEMBL27642283 0.90 ALDH1A1 (0.43) ALDH1A1LMNAMAPTPTGS2TDP1
Sarcosine SCHEMBL9470529 0.88 GABRP (0.41) ALDH1A1LMNAMAPTPTGS2TDP1
(D)-Serine SCHEMBL7446773 0.88 SLC7A5 (0.41) ALDH1A1LMNAMAPTPTGS2TDP1
Alanine SCHEMBL9470521 0.88 GABRP (0.41) ALDH1A1LMNAMAPTPTGS2TDP1
Sarcosine SCHEMBL28157381 0.88 ALDH1A1 (0.41) ALDH1A1LMNAMAPTPTGS2TDP1
Sarcosine SCHEMBL28241384 0.88 ALDH1A1 (0.41) ALDH1A1LMNAMAPTPTGS2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8329745-B2 Small molecule inhibitors of ghrelin O-acyltransferase BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-12-11 — — US disclosed
US-20110318807-A1 Small Molecule Inhibitors of Ghrelin O-Acyltransferase UNIVERSITY OF TEXAS, BOARD OF REGENTS 2011-12-29 — — US disclosed
US-8013015-B2 Small molecule inhibitors of ghrelin O-acyltransferase BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2011-09-06 — — US disclosed
US-20100086955-A1 Small Molecule Inhibitors of Ghrelin O-Acyltransferase UNIVERSITY OF TEXAS, BOARD OF REGENTS 2010-04-08 — — US disclosed
US-4160822-A FOAMING AGENT COMPRISING SUCROSE FATTY ACID ESTER, N-ACYLAMINO ACID OR SALT AND SODIUM MONOFLUOROPHOSPHATE SUNSTAR HAMIGAKI KABUSHIKI KAISHA (JP) 1979-07-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110318807-A1 Small Molecule Inhibitors of Ghrelin O-Acyltransferase MBOAT4, MOGAT2, DGAT1 ALDH1A1 2433/4885LMNA 4852/4885MAPT 1851/4885
US-20100086955-A1 Small Molecule Inhibitors of Ghrelin O-Acyltransferase MBOAT4, MOGAT2, DGAT1 ALDH1A1 2433/4885LMNA 4852/4885MAPT 1851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.