Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28968002 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL11308587 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27686439 | 0.89 | FFAR1 (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Adipic Acid SCHEMBL10397234 | 0.87 | LMNA (0.46) | TSHRTDP1LMNAALDH1A1ALOX15 | |
| Fumaric Acid SCHEMBL4347346 | 0.85 | KDM4E (0.46) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Bicarbonate SCHEMBL5187608 | 0.82 | TSHR (0.39) | TSHRTP53BLMTDP1LMNA | |
| Acrylic Acid SCHEMBL8864275 | 0.81 | LMNA (0.53) | TSHRTP53TDP1LMNAALDH1A1 | |
| Acrylic Acid SCHEMBL11114820 | 0.81 | LMNA (0.53) | TSHRTP53TDP1LMNAALDH1A1 | |
| Acrylic Acid SCHEMBL29589240 | 0.81 | LMNA (0.53) | TSHRTP53TDP1LMNAALDH1A1 | |
| Acrylic Acid SCHEMBL30360549 | 0.81 | LMNA (0.53) | TSHRTP53TDP1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2981560-B1 | CURING OF LIQUID THERMOSETTING RESINS | REICHHOLD LLC 2 (US) | 2021-10-13 | — | — | EP | disclosed |
| EP-2981560-A1 | CURING OF LIQUID THERMOSETTING RESINS | Reichhold, Inc. (US) | 2016-02-10 | — | — | EP | disclosed |
| US-9068045-B2 | Curing of liquid thermosetting resins | REICHHOLD, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| WO-2014165425-A1 | CURING OF LIQUID THERMOSETTING RESINS | REICHHOLD, INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140303315-A1 | CURING OF LIQUID THERMOSETTING RESINS | Polynt Composites USA Inc. | 2014-10-09 | — | — | US | disclosed |
| US-4895926-A | Hydroxyethylnorbornene compounds and a process for their preparation | EASTMAN KODAK COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| US-4855395-A | Hydroxyethylnorbornene compounds and a process for their preparation | EASTMAN KODAK COMPANY (US) | 1989-08-08 | — | — | US | disclosed |
| US-4789602-A | Hydroxyethylnorbornene compounds and a process for their preparation | EASTMAN KODAK COMPANY (US) | 1988-12-06 | — | — | US | disclosed |
| US-3954714-A | Polymerizable urethane compounds and polymers thereof | ICI UNITED STATES INC. (US) | 1976-05-04 | — | — | US | disclosed |