Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10396436 | 0.87 | LMNA (0.49) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| SCHEMBL10396640 | 0.87 | ABCB11 (0.67) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| SCHEMBL10396901 | 0.87 | ABCB11 (0.49) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| SCHEMBL10395929 | 0.87 | ABCB11 (0.49) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| SCHEMBL6751472 | 0.85 | ALDH1A1 (0.51) | LMNAMAPTGAAMEN1ALDH1A1 | |
| SCHEMBL28864463 | 0.84 | ALDH1A1 (0.50) | LMNAMAPTGAAMEN1ALDH1A1 | |
| SCHEMBL10395887 | 0.84 | NPC1 (0.50) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL9998546 | 0.81 | ABCB11 (0.76) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| SCHEMBL10397136 | 0.81 | ABCB11 (0.57) | LMNAABCB11PTGS1ADORA1PTGS2 | |
| SCHEMBL16979055 | 0.81 | ABCB11 (0.57) | LMNAABCB11PTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898874-A | Acetic acid derivatives of 3-aryl-2,1-benzisoxazole and esters and amides thereof | A. H. ROBINS COMPANY, INC. (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0260924-A1 | Antiinflammatory derivatives of 3-aryl-2,1-benzisoxazole | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-03-23 | — | — | EP | disclosed |