Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399120 | 1.00 | CES2 (0.46) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL24704151 | 0.81 | PDE4A (0.51) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL17795993 | 0.79 | PDE4A (0.43) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7570852 | 0.79 | CES2 (0.54) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL28539564 | 0.79 | CES2 (0.54) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11852908 | 0.79 | PLAU (0.56) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL29483453 | 0.79 | CES2 (0.46) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL28519063 | 0.79 | CES2 (0.46) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11852913 | 0.79 | PLAU (0.56) | CES2CES1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL29041273 | 0.79 | CES2 (0.46) | CES2CES1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393940-A1 | Substituted and unsubstituted naphthalenyl-3H-1,2,3,5-oxthiadiazole 2-oxides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-24 | — | — | EP | disclosed |
| US-4895861-A | Novel naphthalenyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-23 | — | — | US | disclosed |