Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503246 | 0.84 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10400033 | 0.82 | HTT (0.52) | KMT2ASMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL10399119 | 0.74 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9502467 | 0.72 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9745131 | 0.71 | ALDH1A1 (0.35) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9745466 | 0.70 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16963334 | 0.70 | KMT2A (0.55) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9844351 | 0.69 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9504237 | 0.69 | SMN1; SMN2 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10554694 | 0.68 | P2RX7 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4973600-A | CONGESTIVE HEART FAILURE, GOUT, DIRUETICS, HYPERURICEMIA | TANABE SEIYAKU CO., LTD. (JP) | 1990-11-27 | — | — | US | disclosed |
| US-4965282-A | DIURETICS | TANABE SEIYAKU CO., LTD. (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0329326-A1 | Benzodioxole derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-23 | — | — | EP | disclosed |