Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 5/20 | 0.42 |
| ▸ | NSD2 | O96028 | 5/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21663984 | 0.89 | ALOX15 (0.43) | STING1ALOX15ATMPGK1NSD2 | |
| SCHEMBL935080 | 0.87 | PGK1 (0.47) | ALOX15ATMPGK1 | |
| SCHEMBL21688901 | 0.87 | ALOX15 (0.39) | STING1ALOX15ATMPGK1NSD2 | |
| SCHEMBL12312875 | 0.87 | ILK (0.47) | ALOX15ATM | |
| SCHEMBL12312873 | 0.87 | PGK1 (0.47) | STING1ALOX15ATMPGK1 | |
| SCHEMBL935523 | 0.84 | CTSS (0.40) | ALOX15ATM | |
| SCHEMBL9796864 | 0.81 | PSMB8 (0.44) | — | |
| SCHEMBL5857526 | 0.77 | NPC1 (0.54) | ALOX15KDM4E | |
| SCHEMBL906609 | 0.77 | CYP1A2 (0.59) | — | |
| SCHEMBL12908847 | 0.77 | GAA (0.57) | NQO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4929636-A | Positive inotrophic benzothiazole and benzothiophene compositions and method of use therefor | AKZO N.V. (NL) | 1990-05-29 | — | — | US | disclosed |
| EP-0158380-B1 | BENZOTHIAZOLE AND BENZOTHIOPHENE DERIVATIVES | AKZO N.V. (NL) | 1989-01-11 | — | — | EP | disclosed |
| US-4665206-A | Benzothiophene derivatives | AKZO N.V. (NL) | 1987-05-12 | — | — | US | disclosed |
| EP-0158380-A1 | Benzothiazole and benzothiophene derivatives | AKZO N.V. (NL) | 1985-10-16 | — | — | EP | disclosed |