Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20886844 | 0.72 | MDM2 (0.38) | DDB1CRBNAKR1B1MDM2 | |
| SCHEMBL10401325 | 0.70 | AKR1B1 (0.38) | AKR1B1 | |
| SCHEMBL20886846 | 0.70 | CA1 (0.36) | DDB1CRBNMDM2 | |
| SCHEMBL10401769 | 0.68 | AKR1B1 (0.52) | AKR1B1 | |
| SCHEMBL10401578 | 0.68 | AKR1B1 (0.62) | AKR1B1 | |
| SCHEMBL10401605 | 0.67 | AKR1B1 (0.42) | AKR1B1 | |
| SCHEMBL28519551 | 0.66 | CA1 (0.36) | MDM2 | |
| SCHEMBL7142836 | 0.61 | MEN1 (0.47) | DDB1CRBNGRIA1CACNG8 | |
| SCHEMBL5764522 | 0.61 | PDE7A (0.46) | GRIA1CACNG8 | |
| SCHEMBL6256987 | 0.60 | PGR (0.44) | GRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946858-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-07 | — | — | US | claimed |
| US-4946858-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-07 | — | — | US | disclosed |
| US-4900739-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORP. (US) | 1990-02-13 | — | — | US | disclosed |