Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.52 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | PPOX | P50336 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401578 | 0.89 | AKR1B1 (0.62) | AKR1B1SRD5A1PPOX | |
| SCHEMBL10401605 | 0.83 | AKR1B1 (0.42) | AKR1B1GHSR | |
| SCHEMBL10401325 | 0.78 | AKR1B1 (0.38) | AKR1B1 | |
| SCHEMBL9383374 | 0.77 | AKR1B1 (0.81) | AKR1B1 | |
| SCHEMBL8804611 | 0.69 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL10401637 | 0.68 | DDB1 (0.35) | AKR1B1 | |
| SCHEMBL21971012 | 0.65 | S100A4 (0.42) | AKR1B1 | |
| SCHEMBL2484250 | 0.64 | AKR1B1 (0.52) | AKR1B1CMA1AHR | |
| SCHEMBL1500415 | 0.63 | ALDH1A1 (0.55) | AKR1B1PPOX | |
| SCHEMBL9686258 | 0.62 | AKR1B1 (0.64) | AKR1B1PPOXCMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946858-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-07 | — | — | US | claimed |
| US-4946858-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-07 | — | — | US | disclosed |
| US-4900739-A | ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORP. (US) | 1990-02-13 | — | — | US | disclosed |