Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 5/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 2/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10402260 | 0.92 | MMP2 (0.53) | ACEMMP9MMP8LTA4HF10 | |
| SCHEMBL10402436 | 0.88 | POLB (0.49) | ACELTA4HF10PLGST14 | |
| SCHEMBL10885166 | 0.86 | ACE (0.64) | ACEMMP9F10PLGST14 | |
| SCHEMBL10404572 | 0.86 | KMT2A (0.49) | ACELTA4HF10PLGST14 | |
| SCHEMBL10404429 | 0.86 | FKBP1A (0.50) | ACEMMP9MMP8MMP13ADAMTS4 | |
| SCHEMBL10403636 | 0.86 | LTA4H (0.57) | ACEMMP9ADAMTS4LTA4HF10 | |
| SCHEMBL10058303 | 0.85 | TMPRSS11D (0.55) | ACERENLTA4HF10PLG | |
| SCHEMBL15251748 | 0.85 | MEN1 (0.52) | ACELTA4HSMN1; SMN2POLBLMNA | |
| SCHEMBL15252105 | 0.85 | MEN1 (0.52) | ACELTA4HSMN1; SMN2POLBLMNA | |
| SCHEMBL15251747 | 0.85 | MEN1 (0.52) | ACELTA4HSMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | claimed |
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0190852-A2 | Dipeptide derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1986-08-13 | — | — | EP | disclosed |