SCHEMBL10408640

SCHEMBL10408640

O=S(=O)(O)c1ccccc1.O=S(=O)(O)c1ccccc1.OC1CCC(O)CC1

nearest known ligand 0.70

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.70
SMN1; SMN2 Q16637 1/20 0.70
CYP2D6 P10635 2/20 0.48
POLB P06746 1/20 0.48
ALDH1A1 P00352 5/20 0.46
CYP2C19 P33261 2/20 0.46
PIK3CA P42336 1/20 0.45
LMNA P02545 1/20 0.43
HTR6 P50406 1/20 0.42
NT5E P21589 1/20 0.41
HSD17B10 Q99714 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
NAPRT Q6XQN6 1/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
GBA1 P04062 1/20 0.40
MMP1 P03956 1/20 0.40
MMP2 P08253 1/20 0.40
MMP9 P14780 1/20 0.40
MMP8 P22894 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11090180 0.92 TSHR (0.64) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL28909814 0.90 TSHR (0.61) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL10408056 0.86 TSHR (0.52) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL30307036 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL30812783 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL30671620 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Benzene SCHEMBL9751882 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL597672 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL3409457 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL2509 0.83 TSHR (1.00) TSHRSMN1; SMN2CYP2D6POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4918046-A DISULFONATES AND COLORLESS OR LIGHT-COLORED COLORING MATERIAL; DISCOLORATION INHIBITION ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1990-04-17 US disclosed