Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.67 |
| ▸ | PDE5A | O76074 | 3/20 | 0.67 |
| ▸ | PDE1A | P54750 | 3/20 | 0.67 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.67 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | MERTK | Q12866 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11459985 | 0.92 | SMN1; SMN2 (0.64) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11452542 | 0.89 | HTT (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11451374 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11463803 | 0.84 | HTT (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Dimethylamine SCHEMBL11024282 | 0.82 | LMNA (0.51) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Arprinocid SCHEMBL31025603 | 0.82 | ADORA2A (0.60) | HTTLMNASMN1; SMN2ALDH1A1TSHR | |
| Arprinocid SCHEMBL126655 | 0.82 | ADORA2A (0.60) | HTTLMNASMN1; SMN2ALDH1A1TSHR | |
| Arprinocid SCHEMBL8375355 | 0.82 | ADORA2A (0.60) | HTTLMNASMN1; SMN2ALDH1A1TSHR | |
| Arprinocid SCHEMBL31379008 | 0.82 | ADORA2A (0.60) | HTTLMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL11151054 | 0.81 | SMN1; SMN2 (0.67) | HTTLMNASMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4189485-A | ANTICOCCIDIAL ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-02-19 | — | — | US | claimed |
| JP-54132595-A | — | — | None | — | — | JP | disclosed |
| US-4900826-A | REACTING METAL SALT OF N6-SUBSTITUTED ADENINE WITH BENZYL HALIDE USING ETHER PHASE TRANSFER CATALYST | KOHJIN CO., LTD. (JP) | 1990-02-13 | — | — | US | disclosed |
| EP-0052959-B1 | PRODUCTION OF PURINE DERIVATIVES AND INTERMEDIATES THEREFOR | Takeda Chemical Industries, Ltd. (JP) | 1986-01-29 | — | — | EP | disclosed |
| US-4423219-A | 6-/2-CHLORO-6-FLUOROBENZYL/AMINO-4-METHYLAMINO-5 -PHENYLAZOPYRIMIDINE, ANTIPROTOZOA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| US-4423219-A | 6-/2-CHLORO-6-FLUOROBENZYL/AMINO-4-METHYLAMINO-5 -PHENYLAZOPYRIMIDINE, ANTIPROTOZOA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| EP-0052959-A1 | Production of purine derivatives and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1982-06-02 | — | — | EP | disclosed |
| EP-0052959-A1 | Production of purine derivatives and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1982-06-02 | — | — | EP | disclosed |
| US-4242517-A | 4-METHYL-1 -HYDROXYMETHYLIMIDAZOLE AND CYSTEAMINE IN BOILING AQUEOUS HYDROCHLORIC ACID | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
| US-4239895-A | Process for producing 1-hydroxymethylimidazoles | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4189485-A | ANTICOCCIDIAL ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-02-19 | — | — | US | disclosed |
| US-4189592-A | Preparation of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole dihydrochloride | BASF AKTIENGESELLSCHAFT (DE) | 1980-02-19 | — | — | US | disclosed |
| JP-S54132595-A | PREPARATION OF PURINE DERIVATIVE | TAKEDA CHEM IND LTD | 1979-10-15 | — | — | JP | disclosed |