Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 12/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 5/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10409157 | 0.90 | HIF1A (0.73) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL13152085 | 0.87 | HIF1A (0.77) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL3404879 | 0.87 | HIF1A (0.77) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL6566408 | 0.87 | HIF1A (0.77) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL9267453 | 0.87 | HIF1A (0.77) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL13103466 | 0.87 | HIF1A (0.77) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL10408762 | 0.86 | NR3C2 (0.61) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL11024468 | 0.86 | HIF1A (0.73) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL10393880 | 0.85 | KMT2A (0.84) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 | |
| SCHEMBL137530 | 0.85 | KMT2A (0.84) | HIF1ACYP3A4HSD17B10CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4912098-A | Antiinflammatory 6 alpha-methylhydrocortisones | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0054786-A1 | 6-Alpha-methyl hydrocortisone derivatives, their preparation and their utilization | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |