Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10409472 | 1.00 | SIGMAR1 (0.48) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| Fumaric Acid SCHEMBL10409444 | 0.99 | POLB (0.48) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| Fumaric Acid SCHEMBL10409412 | 0.99 | POLB (0.48) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| Maleic Acid SCHEMBL10409441 | 0.99 | POLB (0.48) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| Maleic Acid SCHEMBL10409408 | 0.99 | POLB (0.48) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10409586 | 0.91 | SIGMAR1 (0.56) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10409579 | 0.90 | SIGMAR1 (0.55) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10409520 | 0.90 | SIGMAR1 (0.55) | SIGMAR1POLBMEN1KMT2ASMN1; SMN2 | |
| Fumaric Acid SCHEMBL10409548 | 0.89 | MEN1 (0.62) | POLBMEN1KMT2ASMN1; SMN2RAB9A | |
| Maleic Acid SCHEMBL10409547 | 0.89 | MEN1 (0.62) | POLBMEN1KMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895840-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0295010-A1 | Derivatives of alkylaminoalkyl ureas and cyanoguanidines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-12-14 | — | — | EP | disclosed |