Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | IL1RN | P18510 | 2/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041145 | 1.00 | MMP13 (0.43) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| SCHEMBL297301 | 0.86 | HDAC1 (0.42) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| SCHEMBL297820 | 0.85 | MMP8 (0.46) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| SCHEMBL297821 | 0.85 | MMP8 (0.46) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| SCHEMBL8468644 | 0.84 | MMP8 (0.45) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| Hydrochloric Acid SCHEMBL1895224 | 0.84 | MMP8 (0.45) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| Hydrochloric Acid SCHEMBL1895243 | 0.84 | MMP8 (0.45) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| Hydrochloric Acid SCHEMBL1890104 | 0.84 | MMP8 (0.44) | MMP13ALDH1A1MMP8MMP3MMP1 | |
| SCHEMBL296254 | 0.84 | MMP3 (0.47) | ALDH1A1MMP8MMP3MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL1890106 | 0.84 | MMP8 (0.44) | MMP13ALDH1A1MMP8MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969401-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2015-03-03 | — | — | US | disclosed |
| EP-1725528-B1 | SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2013-05-29 | — | — | EP | disclosed |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | ALTANA PHARMA AG (DE) | 2013-03-28 | — | — | US | disclosed |
| US-8399505-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8232297-B2 | Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles | 4SC AG (DE) | 2012-07-31 | — | — | US | disclosed |
| US-8188138-B2 | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors | 4SC AG (DE) | 2012-05-29 | — | — | US | disclosed |
| US-8067615-B2 | Sulphonylpyrroles | 4SC AG (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20110166140-A1 | NOVEL SULPHONYLPYRROLES | MAIER THOMAS | 2011-07-07 | — | — | US | disclosed |
| EP-2272827-A1 | Sulphonylpyrroles as hdac inhibitors | 4SC AG (DE) | 2011-01-12 | — | — | EP | disclosed |
| US-7842820-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20100261721-A1 | Novel Sulphonylpyrroles | MAIER THOMAS | 2010-10-14 | — | — | US | disclosed |
| US-20100261761-A1 | Novel Sulfonylpyrroles | MAIER THOMAS | 2010-10-14 | — | — | US | disclosed |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | NYCOMED GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | NYCOMED GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| EP-1928872-A1 | NOVEL SULPHONYLPYRROLES AS INHIBITORS OF HDAC S NOVEL SULPHONYLPYRROLES | Nycomed GmbH (DE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1928826-A1 | SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS | Nycomed GmbH (DE) | 2008-06-11 | — | — | EP | disclosed |
| US-20070184979-A1 | Novel sulfonylpyrroles | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
| WO-2007039404-A1 | NOVEL SULPHONYLPYRROLES AS INHIBITORS OF HDAC S NOVEL SULPHONYLPYRROLES | NYCOMED GMBH (DE) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039403-A1 | SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS | NYCOMED GMBH (DE) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | MMP13 4558/4885ALDH1A1 1174/4885MMP8 4301/4885 |
| US-20070184979-A1 | Novel sulfonylpyrroles | HDAC1, HDAC4, HDAC3 | MMP13 4633/4885ALDH1A1 389/4885MMP8 4637/4885 |
| US-20110166140-A1 | NOVEL SULPHONYLPYRROLES | HDAC1, HDAC3, HDAC2 | MMP13 4559/4885ALDH1A1 897/4885MMP8 4399/4885 |
| US-20100261761-A1 | Novel Sulfonylpyrroles | HDAC3, HDAC1, HDAC2 | MMP13 4632/4885ALDH1A1 1504/4885MMP8 4723/4885 |
| US-20100261721-A1 | Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | MMP13 4559/4885ALDH1A1 897/4885MMP8 4399/4885 |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC2 | MMP13 4112/4885ALDH1A1 744/4885MMP8 3957/4885 |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | HDAC3, HDAC1, HDAC2 | MMP13 4632/4885ALDH1A1 1504/4885MMP8 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.