Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.73 |
| ▸ | HTR2A | P28223 | 7/20 | 0.73 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | HTR7 | P34969 | 2/20 | 0.65 |
| ▸ | DRD4 | P21917 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414446 | 0.87 | DRD2 (0.73) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL10836447 | 0.87 | DRD2 (0.73) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL12670251 | 0.81 | DRD2 (0.64) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL10834835 | 0.80 | DRD2 (0.70) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL30607591 | 0.79 | ALDH1A1 (0.64) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL2076150 | 0.79 | ALDH1A1 (0.64) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL2076147 | 0.79 | ALDH1A1 (0.60) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL11171863 | 0.78 | DRD2 (0.64) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL11172181 | 0.78 | DRD2 (0.61) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL565864 | 0.77 | KDM4E (0.61) | DRD2HTR2AHTR1AHTR7DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895846-A | CARDIOVASCULAR DISORDERS | BRISTOL-MYERS COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| US-4755512-A | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities | BRISTOL-MYERS COMPANY (US) | 1988-07-05 | — | — | US | disclosed |