Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28750702 | 0.85 | ALDH1A1 (0.43) | RENTSHR | |
| SCHEMBL29270907 | 0.85 | ALDH1A1 (0.43) | RENTSHR | |
| SCHEMBL26741797 | 0.85 | REN (0.40) | CHRNB2CHRNA4CHRNA3RENCA1 | |
| SCHEMBL5190958 | 0.83 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA3CHRNB4REN | |
| SCHEMBL336866 | 0.83 | NR1H2 (0.50) | REN | |
| SCHEMBL1462710 | 0.83 | NR1H2 (0.50) | REN | |
| SCHEMBL994990 | 0.83 | NR1H2 (0.50) | REN | |
| SCHEMBL15360065 | 0.82 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4REN | |
| SCHEMBL4332763 | 0.82 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4REN | |
| SCHEMBL15360066 | 0.82 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4943578-A | ANALGESICS; CEREBRAL ANTIISCHEMIC AGENTS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0343900-A2 | Piperazine compounds | GLAXO GROUP LIMITED (GB) | 1989-11-29 | — | — | EP | disclosed |