Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690140 | 0.78 | NPSR1 (0.32) | POLBALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL17674048 | 0.78 | DHFR (0.42) | TAAR1MEN1KMT2AEGFRCSF1R | |
| SCHEMBL1667246 | 0.74 | ALDH1A1 (0.38) | POLBALDH1A1ALOX15 | |
| SCHEMBL17049294 | 0.74 | POLB (0.32) | POLB | |
| SCHEMBL4458935 | 0.74 | NPSR1 (0.47) | POLBALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL6905225 | 0.71 | KMT2A (0.46) | POLBALDH1A1TDP1L3MBTL1MEN1 | |
| SCHEMBL398536 | 0.71 | NPSR1 (0.44) | POLBALDH1A1TDP1L3MBTL1MEN1 | |
| SCHEMBL11342835 | 0.71 | ESR1 (0.35) | ALDH1A1MAPTL3MBTL1KDM4ECYP1A2 | |
| SCHEMBL12668168 | 0.70 | ALDH1A1 (0.44) | POLBALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL4268460 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | claimed |