SCHEMBL104233

SCHEMBL104233

FC(F)(F)Oc1ccc(CBr)cc1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
TSHR P16473 1/20 0.47
SLC6A4 P31645 3/20 0.45
DAO P14920 1/20 0.42
EPHX2 P34913 2/20 0.42
MAPT P10636 1/20 0.42
GRIN2B Q13224 2/20 0.41
BCHE P06276 1/20 0.41
ACHE P22303 1/20 0.41
SLC6A3 Q01959 2/20 0.41
NR1H4 Q96RI1 1/20 0.41
KDM1A O60341 1/20 0.41
GPR84 Q9NQS5 1/20 0.41
CHRM5 P08912 1/20 0.41
EPHX1 P07099 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10078425 0.94 KIF11 (0.45) ALDH1A1TSHRSLC6A4
SCHEMBL20636723 0.94 EPHX2 (0.44) ALDH1A1TSHRSLC6A4DAOEPHX2
SCHEMBL508197 0.94 SLC6A4 (0.49) ALDH1A1TSHRSLC6A4DAOEPHX2
SCHEMBL508826 0.89 CYP2D6 (0.41) ALDH1A1TSHRSLC6A4DAOBCHE
SCHEMBL508827 0.89 CYP2D6 (0.41) ALDH1A1TSHRSLC6A4DAOBCHE
SCHEMBL3051500 0.83 DAO (0.47) ALDH1A1TSHRSLC6A4DAOEPHX2
SCHEMBL7762320 0.83 ALDH1A1 (0.38) ALDH1A1TSHRSLC6A4DAOGPR84
SCHEMBL4218815 0.83 ALDH1A1 (0.41) ALDH1A1TSHRSLC6A4EPHX2GRIN2B
SCHEMBL2092054 0.81 SLC6A4 (0.56) ALDH1A1TSHRSLC6A4DAOEPHX2
SCHEMBL5753027 0.81 PTGES2 (0.40) ALDH1A1TSHRSLC6A4MAPTEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1548 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431278-A Aromatic oxetanes and their use in encapsulation compositions 华为技术有限公司 2025-02-14 CN claimed
CN-119264013-A Preparation method of (1-arylmethyl-3-aryl-1-trifluoromethyl propyl) aromatic compound 南京工业大学 2025-01-07 CN claimed
CN-119101052-A Matrine-triazole derivative and synthesis method thereof 吉林医药学院 2024-12-10 CN claimed
CN-114249747-A New synthesis process of nitroimidazole pyran medicine for treating wide drug-resistant tuberculosis 苏州虞美景盛新药开发有限公司 2022-03-29 CN claimed
CN-110483549-B Preparation method of nitroimidazole pyran antituberculosis drug 沈阳药科大学 2021-03-05 CN claimed
CN-107915747-B Synthetic method of PA-824 瑞阳制药股份有限公司 2020-11-10 CN claimed
JP-4360875-A None JP disclosed
JP-4264048-A None JP disclosed
US-12637414-B2 Arylamides and methods of use thereof GENZYME CORPORATION (US) 2026-05-26 US disclosed
US-12630498-B2 Arylamides and methods of use thereof GENZYME CORPORATION (US) 2026-05-19 US disclosed
CN-119431371-B Beta-carbolin 3,6, 9-modified derivative and preparation method and application thereof 沈阳药科大学 2026-05-19 CN disclosed
US-12630521-B2 Arylamides and methods of use thereof GENZYME CORPORATION (US) 2026-05-19 US disclosed
CN-122055361-A Fascin inhibitors 北京双鹤润创科技有限公司 2026-05-15 CN disclosed
JP-H04264048-A TRIFLUOROMETHYL COMPOUND CHISSO CORP 1992-09-18 JP disclosed
EP-0442306-A2 (4E-cyclohexyl-3-butenyl)phenyl derivatives F. Hoffmann-La Roche AG (CH) 1991-08-21 EP disclosed
US-5006543-A Diphenylethane derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-04-09 US disclosed
EP-0354689-A1 Diphenylethane derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-02-14 EP disclosed
EP-0008854-B1 PENTADIENONE HYDRAZONE, AND ITS USE AS INSECTICIDAL AGENT AMERICAN CYANAMID COMPANY (US) 1983-03-09 EP disclosed
EP-0008854-A1 Pentadienone hydrazone, and its use as insecticidal agent AMERICAN CYANAMID COMPANY (US) 1980-03-19 EP disclosed
US-4191768-A Pentadienone hydrazones, method for preparing the same, and insecticidal use thereof AMERICAN CYANAMID COMPANY (US) 1980-03-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12637414-B2 Arylamides and methods of use thereof CFTR, CLIC1, ABCC1 ALDH1A1 630/4885TSHR 715/4885SLC6A4 816/4885
US-12630521-B2 Arylamides and methods of use thereof CFTR, CLIC1, CLCN2 ALDH1A1 905/4885TSHR 497/4885SLC6A4 942/4885
US-12630498-B2 Arylamides and methods of use thereof CFTR, CLIC1, CLCN2 ALDH1A1 775/4885TSHR 337/4885SLC6A4 1208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.