Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956576 | 0.76 | GCGR (0.46) | STAT1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL10424693 | 0.75 | NPC1 (0.43) | STAT1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL8051661 | 0.72 | MEN1 (0.51) | STAT1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL29222898 | 0.70 | NPC1 (0.45) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL2509825 | 0.70 | ALDH1A1 (0.44) | KDM4EMAPTMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL10914043 | 0.69 | GPR84 (0.39) | MEN1KMT2ANPC1RAB9AADORA2A | |
| SCHEMBL8878362 | 0.69 | SQOR (0.48) | KDM4EMAPTMEN1KMT2ASQOR | |
| Bromide SCHEMBL4449437 | 0.68 | GCGR (0.41) | KDM4ESMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL7610953 | 0.67 | GRM2 (0.58) | STAT1KDM4EMAPTKMT2ASMN1; SMN2 | |
| Bromide SCHEMBL20742872 | 0.67 | SNCA (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4925852-A | TREATMENT OR PROPHYLAXIS OF ARTERIOSCLEROSIS OR HYPERCHOLESTEROLEMIA | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-15 | — | — | US | disclosed |